BrainLab's most recent publication in the Journal of Visualized Experiments (JoVE):
Ramirez, J., Scott, C. J. M., McNeely, A. A., Berezuk, C., Gao, F., Szilagyi, G. M., et al. Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly. J. Vis. Exp. (86) (2014).
"Lesion Explorer (LE) is a semi-automatic, image-processing pipeline developed to obtain regional brain tissue and subcortical hyperintensity lesion volumetrics from structural MRI of Alzheimer's disease and normal elderly. To ensure a high level of accuracy and reliability, the following is a video-guided, standardized protocol for LE's manual procedures."
Pubmed link: http://www.ncbi.nlm.nih.gov/pubmed/24797507